Role of SARS-CoV-2 neurotropism and neuroinvasion in COVID-19 patients disease severity

The disease caused by the new SARS-CoV-2 coronavirus (COVID-19) spread rapidly from China to entire world. Approx-imately one third of SARS-CoV-2-infected patients have neurological disorders, especially those classified as severe cases and that require mechanical ventilation. On other hand, almost nine out 10 admitted an Intensive Care Unit could not breathe spontaneously, thus requiring invasive non-invasive ventilatory support. So far, whether early neurolog-ical disorders such hyposmia or anosmia, dysgeusia ageusia, headache vertigo are significant in progression form they related entry central nervous system via peripheral nerves has been determined. Considering great similarity between SARS-CoV SARS-CoV-2, severity condition leads death cannot be explained solely lung involvement, it is important determine potential invasion partially responsible for respiratory component observed pa-tients with COVID-19.